Manipulating novel materials and engineering new device platforms are the core driving force for both fundamental physics discovery and technical engineering applications, as highlighted in the recent advances in two-dimensional van der Waals heterostructures. In this talk, I aim to demonstrate how an interdisciplinary combination of materials synthesis, processing, and characterization, can be used to engineer high-quality van der Waals interfaces. I will exemplify the transition metal dichalcogenides system with a case study on monolayer/twisted bilayer WSe₂. Finally, I will anticipate current challenges and future opportunities that may unlock a new regime to probe their novel behavior and pave a new way for next-generation electronics.